SSRIs or when SSRIs are administered with other medications that also release serotonin (such as dextromethorphan, tramadol, and St. John's
Opiates with MAOIs, SSRIs, SNRIs or triptans; Tramadol with mirtazapine and olanzapine; Dextromethorphan with SSRIs, amitriptyline or chlorpheniramine
Tramadol. Both tramadol and SSRIs lower seizure threshold. Serotonin syndrome reported with concurrent use. Use the combination of tramadol and an SSRI very.
About one-third of respondents prescribed tramadol and indicated they were aware of the interaction with SSRI s. About one-fifth deliberately avoided tramadol because an interaction with SSRI s was identified. However, there was no difference in actual tramadol prescriptions: 23.8% of SSRI-users received tramadol, versus 24.6% of non-SSRI
There are 2 possible explanations of serotonin syndrome secondary to the combination of SSRIs and tramadol. First, the literature suggests that higher plasma concentrations of tramadol and/or SSRIs escalate the risk of serotonin syndrome.
SSRIs are widely used as antidepressants, but frequent prescribing of tramadol tramadol and SSRIs. (Clinical Therapeutics 2024;37[8]
Keywords. Tramadol, Ultram, SSRI, Serotonin Syndrome, Tramadol Induced Serotonin Syndrome, Tramadol Flexeril Interaction, Tramadol Flexeril Drug Interaction
Tramadol. Both tramadol and SSRIs lower seizure threshold. Serotonin syndrome reported with concurrent use. Use the combination of tramadol and an SSRI very.
About one-third of respondents prescribed tramadol and indicated they were aware of the interaction with SSRI s. About one-fifth deliberately avoided tramadol because an interaction with SSRI s was identified. However, there was no difference in actual tramadol prescriptions: 23.8% of SSRI-users received tramadol, versus 24.6% of non-SSRI
Comments
As a medical professional however, I enjoyed the use of the SSRI as a very clever and creative plot device but have to mention that these results are not typical. Low dise SSRIs ARE commonly used for males with premature ejaculation problems, BUT the therapeutic window us VERY narrow. More often, the result is erectile dysfunction or total anorgasmia. I hope folks do not rush out and get an SSRI thinking they will last forever. All in all however, my most sincere and enthusiastic compliments on an amazing story. Thank you for sharing!
As to this story, it was racing around in my skull, getting in the way of me working on other stories. It was just easier to write it and post it than to try to ignore it.
Since I got a ping on this in private: if you know anyone taking SSRI medication, nobody should quit those without close physician supervision. Doing so can increase suicidal impulses.
Thanks again for the feedback,
Todd172