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Author: Admin | 2025-04-28
May also block histamine and muscarine receptors on your nerve cells. Muscarine and histamine trigger your nerve cells to release acetylcholine, a neurotransmitter that helps control muscle contracting and plays a role in memory, thinking, and learning.Examples of tricyclic antidepressants include:Amitriptyline (Elavil)AmoxapineClomipramineDesipramineDoxepin (Sinequan)Imipramine (Tofranil)MaprotilineNortriptyline (Pamelor)ProtriptylineTrimipramineThe most common side effects for tricyclic antidepressants include:DrowsinessConfusionBlurred vision and dilated pupilsDry mouth, eyes, and skinFast heart rateVomitingMuscle weaknessMonoamine oxidase inhibitors (MAOIs)The first antidepressants discovered, MAOIs block an enzyme called monoamine oxidase, which helps serotonin, norepinephrine, and dopamine neurotransmitters work. Doctors don't prescribe them as much anymore because there's a risk for interactions with your other medicines, and the side effects tend to be more challenging than those of other antidepressants. Examples of MAOIs include:Isocarboxazid (Marplan)MoclobemidePhenelzine (Nardil)Selegiline (EMSAM)Tranylcypromine (Parnate) The most common side effects of MAOIs include sexual dysfunction and serotonin syndrome. Serotonin syndrome is when you have too much serotonin in your nerve cells. Symptoms of too much serotonin include:Nervousness or anxietyNausea and vomiting DiarrheaDilated pupilsMuscle twitching, involuntary contractions, spasms, and rigiditySweating and shiveringSide-to-side eye movementsIn serious cases, confusion, delirium, fast heart rate, high blood pressure, fever, seizures, and loss of consciousnessAtypical antidepressants and N-methyl-D-aspartate (NMDA) antagonistsThese two types of antidepressants work slightly differently from the ones above, and also from each other. Examples of atypical antidepressants include:Agomelatine, which increases levels of melatonin, dopamine, and norepinephrineBupropion (Wellbutrin), which increases levels of norepinephrine and dopamineMirtazapine (Remeron), which increases levels of norepinephrine and dopamineNMDA antagonists keep two neurotransmitters called glutamate and gamma-aminobutyric acid (GABA) from binding
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